Clinician hesitation prior to clozapine initiation: is it justifiable?
نویسنده
چکیده
Clozapine has been endorsed by national clinical guidelines for 10 years and yet underutilisation and delay to initiation remain rife. Although there will be good clinical reasons for clozapine not being initiated for some patients, it is hypothesised here that for others, clinicians' attitudes and preferences are the most likely predictive factors.
منابع مشابه
A23 23..23
Two papers in the Journal this month examine patterns of prescribing practice. With established clinical guidelines for the management of individuals with treatment-resistant schizophrenia in mind, Howes et al (pp. 481–485) reviewed prescribing practices prior to commencement of clozapine for a sample of patients managed within one mental health service. The authors found evidence of a signific...
متن کاملAdherence to treatment guidelines in clinical practice: study of antipsychotic treatment prior to clozapine initiation.
BACKGROUND Clozapine is the only antipsychotic drug licensed for treatment-resistant schizophrenia but its use is often delayed. Since previous studies, national guidelines on the use of clozapine and other antipsychotics have been disseminated to clinicians. AIMS To determine the theoretical delay to clozapine initiation and to quantify the prior use of antipsychotic polypharmacy and high-do...
متن کاملAntipsychotic polypharmacy and augmentation strategies prior to clozapine initiation: a historical cohort study of 310 adults with treatment-resistant schizophrenic disorders.
RATIONALE Antipsychotic polypharmacy (APP) is commonly used in schizophrenia despite a lack of robust evidence for efficacy, as well as evidence of increased rates of adverse drug reactions and mortality. OBJECTIVES We sought to examine APP and the use of other adjunctive medications in patients with treatment-resistant schizophrenic disorders (ICD-10 diagnoses F20-F29) immediately prior to c...
متن کاملClozapine use in childhood and adolescent schizophrenia: A nationwide population-based study.
Early onset schizophrenia (EOS) begins in childhood or adolescence. EOS is associated with poor treatment response and may benefit from timely use of clozapine. This study aimed to identify the predictors of clozapine use in EOS and characterize the clinical profile and outcome of clozapine-treated youths with schizophrenia. We conducted a nationwide population-based study using linked data fro...
متن کاملکاربرد داده های EEG به عنوان شاخص پیش بینی اثربخشی کلوزاپین دردرمان بیماران مبتلا به اسکیزوفرنی مقاوم به درمان
Background and purpose: EEG is used as a diagnostic tool in the diagnosis and prognosis of disease spread. Among the psychiatric illnesses that can utilize EEG to measure response to treatment, schizophrenia can be noted. Many investigations on the application of data EEG as a predictor of treatment response in patients with schizophrenia refractory to clozapine has been done in order to res...
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عنوان ژورنال:
- The British journal of psychiatry : the journal of mental science
دوره 201 6 شماره
صفحات -
تاریخ انتشار 2012